1% Retinol Treatment

CLINICAL 1% retinol features a potent blend of three peptides and vitamin C to help skin look and feel more youthful. The sheer, lightweight formula visibly improves skin’s resilience, softens lines and wrinkles, minimizes pores and fades the look of discoloration over time.

A blend of four peptides and stabilized vitamin C team up in this potent 1% retinol formula to help visibly reduce signs of aging for a youthful-looking glow. Crafted in a sheer, lightweight formula, it visibly improves skin’s resilience, softens wrinkles & fades the look of discoloration over time.

Smooth 1–2 pea-sized pumps over face & neck, avoiding contact with eyes.

Note:Some people may experience a delayed sensitized reaction to 1% retinol. Do not assume that if no reaction is seen after a few applications that you can apply this product more frequently. Pay close attention to how your skin responds and adjust usage accordingly.

Key Ingredients: Retinol, Tetrahexyldecyl Ascorbate, Palmitoyl Tetrapeptide-7, Salix Alba Extract, Dipotassium Glycyrrhizate, Arctium Lappa, Glycine Soja Sterols, Glycerin, Sodium Hyaluronate, Allantoin, Avena Sativa Kernel Extract, Lecithin, Dimethicone, Palmitoyl Tripeptide-1, Laurdimonium Hydroxypropyl Hydrolyzed Soy Protein, Glycyrrhiza Glabra, Ceramide NS, Palmitoyl Hexapeptide-12, Tocopheryl Acetate

All Ingredients: Water (Solvent | Good), Dimethicone (Silicone, Emollient | Best), Glycerin (Humectant, Texture Enhancer, Solvent | Best), Butylene Glycol (Humectant, Texture Enhancer | Good), Isononyl Isononanoate (Emollient | Good), Castor Isostearate Succinate (Emollient, Plant Extracts | Good), Glyceryl Stearate (Emollient, Emulsifier, Cleansing Agent | Good), C12-15 Alkyl Benzoate (Emollient, Texture Enhancer, Solvent | Good), Dimethicone Crosspolymer (Silicone, Texture Enhancer, Polymer | Good), PEG-33 (Polymer, Humectant, Solvent | Good), Polysorbate 20 (Cleansing Agent, Emulsifier | Good), Behenyl Alcohol (Texture Enhancer, pH Adjuster/Stabilizer | Good), PEG-100 Stearate (Cleansing Agent, Emulsifier, pH Adjuster/Stabilizer | Good), Pentaerythrityl Tetraisostearate (Emollient, Texture Enhancer | Good), Polymethylsilsesquioxane (Silicone, Film-Forming Agent, Suspending/Dispersing Agent | Good), Tetrahexyldecyl Ascorbate (Antioxidant | Best), Retinol (Antioxidant, Retinoids | Best), Ceramide NG (Emollient | Best), Palmitoyl Tetrapeptide-7 (Peptides | Best), Palmitoyl Hexapeptide-12 (Peptides | Best), Sodium Hyaluronate (Humectant, Antioxidant | Best), Dipotassium Glycyrrhizate (Plant Extracts, Antioxidant | Best), Glycyrrhiza Glabra (Licorice) Root Extract (Antioxidant, Plant Extracts | Best), Avena Sativa (Oat) Kernel Extract (Plant Extracts, Antioxidant | Best), Arctium Lappa (Antioxidant, Plant Extracts | Best), Salix Alba Extract (Plant Extracts, Antioxidant | Best), Glycine Soja Sterols (Emollient, Plant Extracts, Antioxidant | Best), Lecithin (Emollient, Emulsifier, Cleansing Agent | Best), Allantoin (Plant Extracts | Best), Tocopheryl Acetate (Antioxidant | Best), Hydrolyzed Soy Protein (Plant Extracts, Antioxidant | Best), Sorbitan Laurate (Cleansing Agent, Emulsifier | Good), Acetyl Dipeptide-1 Cetyl Ester (Peptides | Best), Disodium EDTA (Chelating Agent | Good), Hydroxyethylcellulose (Texture Enhancer, Film-Forming Agent, pH Adjuster/Stabilizer | Good), Palmitoyl Tripeptide-1 (Peptides | Best), Sodium Hydroxide (pH Adjuster/Stabilizer | Average), Tribehenin (Humectant, Occlusive/Opacifying Agent | Good), Caprylyl Glycol (Preservative, Plant Extracts | Good), Ethylhexylglycerin (Preservative, Humectant | Good), Pentylene Glycol (Humectant, Solvent, Preservative | Good), PEG-75 Shea Butter Glycerides (Emollient, Cleansing Agent | Good), PPG-12/SMDI Copolymer (Film-Forming Agent, Humectant | Good), PEG-10 Phytosterol (Cleansing Agent, Emulsifier | Good), PEG-8 Dimethicone (Silicone, Polymer, Humectant | Good), PEG-14 (Polymer, Humectant | Good), Magnesium Aluminum Silicate (Texture Enhancer, Absorbent | Good), Arachidyl Glucoside (Cleansing Agent, Emulsifier | Good), Arachidyl Alcohol (Emollient, Texture Enhancer | Good), Sclerotium Gum (Texture Enhancer, pH Adjuster/Stabilizer | Good), Carbomer (Texture Enhancer, Polymer, pH Adjuster/Stabilizer | Good), Phenoxyethanol (Preservative | Good), Benzoic Acid (Preservative, pH Adjuster/Stabilizer | Good)

Ingredient Spotlight:

• Retinol: One of the most recognized anti-aging ingredients, this powerhouse has multiple benefits for skin. With over seven decades of research proving its effectiveness, it’s used in several strengths and types of products to deliver visible results. Name for the entire vitamin A molecule; Research proves its anti-aging abilities; Helps tell skin how to look and behave younger
• Tetrahexyldecyl Ascorbate: Highly stable form of vitamin C that protects skin from oxidative damage and collagen breakdown. Oil-soluble, more stable form of vitamin C; Can help preserve’s skin collagen; Antioxidant helps fight damaging free radicals
• Palmitoyl Tetrapeptide-7: This peptide blends four amino acids with a fatty acid to enhance penetration, where it goes to work quieting factors in skin that trigger irritation and damage to skin’s supportive elements. Composed of four amino acids + palmitic acid; Can fight factors in skin that cause irritation; Ongoing use helps restore a firmer feel
• Salix Alba Extract: Plant extract whose soothing antioxidant benefits help support blemish-prone skin. Plant extract with proven skin-soothing, antioxidant benefits; Contains beneficial compounds of salicin, polyphenols, and flavonoids; Can play a supportive role with salicylic acid for blemish-prone skin
• Dipotassium Glycyrrhizate: This licorice derivative has strong antioxidant and skin soothing properties. Derived from licorice; Has antioxidant benefits; Strong anti-inflammatory properties
• Arctium Lappa: AKA burdock, this plant produces many skin care ingredients that have antioxidant, soothing and hydrating properties. Also known as burdock; Contributes to skin’s environmental defense; Works to soothe and lightly hydrate skin
• Glycine Soja Sterols: Glycine soja sterols, derived from soybeans, have both moisturizing and antioxidant properties. Have moisturizing and antioxidant properties; Solid complex alcohols derived from wild soybean plants; Type of phytosterol
• Glycerin: A naturally occurring substance in skin that helps retain moisture. It is used in skin care products to help defend against dryness. Found naturally in skin; Helps skin retain moisture; Encourages a healthy look and feel
• Sodium Hyaluronate: The more bio-available, salt form of hyaluronic acid. I’s considered an excellent moisturizer, helping skin retain water so it looks and feels smoother. Salt form of hyaluronic acid; Excellent skin-replenishing ingredient; More readily absorbed into skin than hyaluronic acid
• Allantoin: An ingredient that can be naturally derived or made synthetically. It has skin-soothing and moisturizing properties, making it an excellent inclusion in products designed for sensitive skin. Can soothe skin; Has skin moisturizing properties; Helps mitigate skin’s response to active ingredients
• Avena Sativa Kernel Extract: This extract from oats has antioxidant benefits for skin and is well-known for its potent soothing properties. Good source of antioxidants; Exhibits impressive skin-soothing abilities; Suitable for even the most sensitive skin
• Lecithin: Beneficial properties include emolliency (think skin softening), water-binding (to boost hydration), and emulsifying (to help water + oil ingredients mesh in a formula). Can also be used to encapsulate ingredients for improved dermal delivery. Assists in improving skin’s moisture retention; Is also emulsifying agent; Long track record of safety in skin care products
• Dimethicone: An skin-softening silicone known for its permeable (think breathable) barrier that helps skin retain hydration. It has a uniquely silky, non-greasy feel. Commonly used emollient, known for its gentleness and silky feel; Recognized as a skin protectant (in concentrations 1-30%) by the U.S. FDA; Popular in oil-free moisturizers, thanks to its hydration-enhancing, non-greasy finish
• Palmitoyl Tripeptide-1: Synthetic peptide proven to strengthen skin’s underlying supportive elements and visibly reduce signs of sun damage such as wrinkles and rough texture. Helps strengthen skin’s supportive elements; Can minimize the appearance of wrinkles; Designated as a “signal peptide”
• Laurdimonium Hydroxypropyl Hydrolyzed Soy Protein: This hydrating ingredient conditions skin and helps reduce static when used in hair care products. Provides hydration in skin care products; Made from modifying lauric acid and soy protein; Reduces static electricity in hair care products
• Glycyrrhiza Glabra: Offers soothing and anti-aging benefits. AKA licorice root extract; Offers skin-soothing properties; Can be effective in improving the look of an uneven skin tone
• Ceramide NS: Provides barrier strengthening properties and helps skin retain moisture for a more hydrated, supple appearance. Natural skin component that aids barrier strength; Aides in improving skin’s texture and hydration; Helps boost skin’s defenses
• Palmitoyl Hexapeptide-12: This lab-made peptide matches a sequence of amino acids found in skin. As such, skin recognizes and can understand the signals the peptide sends, which leads to a smoother, more youthful appearance. A synthetic peptide that matches a sequence of amino acids found in skin; Signals skin to look younger by boosting its firm feeling; Creates a supple surface by strengthening skin’s barrier
• Tocopheryl Acetate: A form of vitamin E frequently used in cosmetics for its antioxidant benefit. Also referred to as tocopherol acetate; One of many forms of vitamin E; Offers anti-aging benefits due to its antioxidant properties

Journal of Cosmetic Dermatology,March 2016, issue 1, pages 49-57
Journal of Drugs in Dermatology, March 2015, issue 3, pages 271-280
Phytotherapy Research, August 2015, issue 8, pages 1117-1122
Skin Research and Technology, August 2013, issue 3, pages 291-298
Inflammopharmacology, October 2011, issue 5, pages 245-254
Journal of Cosmetic Dermatology, December 2008, issue 4, pages 281-289
Indian Journal of Dermatology and Venereology, March-April 2012, issue 2, pages 142-145
American Journal of Clinical Dermatology, 2003, issue 2, pages 107-129
Evidence Based Complementary Alternative Medicine, 2013, volume 2013, article 827248
Pharmacology and Physiology, March-April 2005, issue 2, pages 81-87
Dermato-Endocrinology, July 2012, issue 3, pages 253-258
Indian Dermatology Online Journal, April-June 2013, issue 2, pages 143-146

What’s the difference between CLINICAL 1% Retinol Treatment and other Paula’s Choice high-strength retinols?

The main difference between CLINICAL 1% Retinol Treatment and our other high-strength retinol formulas is texture. CLINICAL 1% Retinol Treatment’s lotion texture is ideal if you have normal to dry skin.1% Retinol Boosterhas a thinner, fluid texture that works best if you have oily, combination and/or breakout-prone skin.CLINICAL 0.3% Retinol + 2% Bakuchiol Treatmentcontains a slightly lower amount of retinol (0.3%) but is still considered a high-strength option because it’s paired with 2% bakuchiol, an ingredient with similar benefits to retinol that amplifies retinol’s benefits. This treatment may be preferred if you have sensitive skin. The CLINICAL Pro Retinaldehyde Dual-Retinoid Treatment is a fast-absorbing light lotion that combinesretinaldehyde(also known as retinal) and oleyl adapalenate (known as Adapinoid ®) to address multiple signs of aging as well as rough, bumpy texture and blemish/pore-related concerns. It is considered a professional strength, yet gentle, option for those seeking dermatologist-level results without needing a prescription. If you have had increased sensitization from using the CLINICAL 1% Retinol Treatment in the past, you may want to consider trying the CLINICAL Pro Retinaldehyde Dual-Retinoid Treatment to see how your skin responds to this formula.

How does CLINICAL 1% Retinol Treatment compare to prescription retinoids?

This product contains retinol, which is weaker than prescription retinoids but produces comparable anti-aging and pore-minimizing results over time. This 1% retinol is comparable to a prescription retinoid with 0.02 tretinoin and contains numerous soothing ingredients, so it has a much lower risk of side effects like redness, flaking and sensitivity. For optimum results, consistent use and daily sun protection are crucial.

What should I do if I have a skin reaction to retinol?

If your skin becomes very dry, red, or irritated, scale back retinol usage (for example, use it less often and apply a moisturizer) and see if your skin settles over the next 1–2 weeks. If irritation persists or feels severe, discontinue use and consider checking with a healthcare provider.

Not everyone experiences it, but retinoids can sometimes cause a temporary “purging” period as they help increase skin cell turnover—this may bring existing congestion to the surface. Remember, purging is temporary so be patient and know that this surface cell turnover will bring about smooth, radiant benefits in the end.

If I see great results after the first or second use, should I use retinol every day?

Because skin has a delayed response to retinol, we recommend using this product at a reduced rate for the first two weeks. If your skin is responding well, you can increase to once per day if desired.

How do I know which retinol strength to use?

Retinol is a powerhouse anti-aging ingredient that’s proven to be effective even in concentrations as low as 0.01%. You can choose to use low, medium, high, or proretinol strengthsbased on your specific skin concerns.

Do I build up a retinol tolerance so that I must move up to 1% even if I start out with a milder retinol strength? Will my retinol tolerance increase? If so, will I have to use a higher retinol strength?

Not necessarily. Everyone’s skin retains retinol differently so a milder formula may work better for some while others may need a stronger formula. We recommend evaluating your results with your current retinol and possibly increasing frequency of use prior to switching to a stronger retinol. If your skin is doing well with your current retinol, there’s no need to switch.

I keep pushing on the pump, but no product is coming out.

This product utilizes an airless pump, which needs to be primed before first use. See this guide in our Help Center to learnhow to prime an airless pump.

When do I use retinol in my routine?

In general, most people can use retinol daily, after cleansing, toning and exfoliating. Because this product contains a potent strength of retinol, we recommend introducing it slowly into your routine and alternating days until you know how it works for you. You can use retinol either during the daytime or at night, depending on personal preference. If using it during the day, be sure to liberally apply a sunscreen rated SPF 30+ as your routine last step.

Is retinol safe during pregnancy or while breastfeeding?

You shouldavoid using retinol if you’re pregnant or breastfeeding. As an alternative, consider products with niacinamide, vitamin C, or peptides, and check with your healthcare provider before starting any new skincare regimen during this time.

How long should you wait to apply moisturizer after retinol?

You can apply moisturizer immediately after using retinol. There’s no need to wait between applying retinol products and your moisturizer or any other product.

At what age should you start using retinol?

You can start using retinol at any age. Many blemish-prone people start using it as teenagers to help with clogged pores, but there’s no right (or wrong) age to start using this multifaceted antioxidant.

What ingredients can I use with the CLINICAL 1% Retinol Treatment?

Retinol can pair well with many skincare ingredients, but it’s best to introduce combinations gradually, especially if your skin is sensitive. Retinol works well with niacinamide (to help support the skin barrier and calm visible sensitivity) and can be paired with vitamin C (many people prefer vitamin C in the morning and retinol at night). If you use AHA or BHA exfoliants, consider alternating days/nights or using your exfoliant at a different time of day.